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Appala Raju, N.
- Visible Extractive Spectrophotometric Estimation of Teicoplanin in Bulk and in Pharmaceutical Formulations
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Authors
Affiliations
1 Analytical Department, Vishnu Chemicals Limited, Hyderabad, IN
2 Department of Chemistry, S.K. University, Ananthpur, IN
3 Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road #3, Banjara Hills, Hyderabad-500034, IN
1 Analytical Department, Vishnu Chemicals Limited, Hyderabad, IN
2 Department of Chemistry, S.K. University, Ananthpur, IN
3 Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road #3, Banjara Hills, Hyderabad-500034, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 710-713Abstract
Three simple, accurate, rapid and sensitive methods (A, B and C) have been developed for the estimation of Teicoplanin in pharmaceutical dosage form. The Method A is based on reaction of Teicoplanin with ferric chloride and 1,10-phenanthroline to form a blood red colored chromogen. The Method B is based on reaction of Teicoplanin with ferric chloride 2, 2’ bipyridyl to form blood colored chromogen. The Method C is based on the reduction of Ferric ions of the reagent Ferric chloride to Ferrous ions by the drug, which further in the presence of potassium ferricyanide as oxidizing agent produces blue colored chromogen measured at 700 nm, against reagent blank. These Methods exhibit maximum absorption at 510 nm, 520 nm and 720 nm respectively and obey the Beer’s law in the concentration range of 5-30 mcg/ml, 5-50 mcg/ml and. 1-10 mcg/ml respectively. The Methods have been statistically evaluated and were found to be precise and accurate. The proposed methods are economical and sensitive for the estimation of Teicoplanin in bulk drug and in its formulations.Keywords
UV-Visible Spectrophotometry, Teicoplanin, Ferric Chloride, 1, 10-Phenanthroline, 2, 2’ Bipyridyl and Potassium Ferricyanide.- The Estimation of Irinotecan HCl in Parenterals by RP-HPLC
Abstract Views :178 |
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Authors
V. Kiran Kumar
1,
N. Appala Raju
2,
Namratha Rani
2,
J. V. L. N. Seshagiri Rao
3,
T. Satyanarayana
2
Affiliations
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, A.P., IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road#3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., IN
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, A.P., IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road#3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 54-56Abstract
A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Irinotecan HCl in tablet dosage form. A X-Terra RP C18, 250×4.6 mm i.d, 5 μm partical size, with mobile phase consisting of Methanol and 0.01 M Ammonium Acetate containing 0.1% formic acid and methanol in the ratio of 50:50 v/v was used. The flow rate was 1 ml/min and the effluents were monitored at 250 nm. The retention time was 4.69 min. The detector response was linear in the concentration of 120-360 mcg/ml. The respective linear regression equation being Y=166582.24x+86439.5. The limit of detection and limit of quantification was 0.06 and 0.18 mcg/ml respectively. The percentage assay of Irinotecan HCl was 99.09%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Irinotecan HCl in bulk drug and in its pharmaceutical dosage form.Keywords
Irinotecan HCl, RP-HPLC, Estimation, and Tablets.- The Estimation of Paclitaxel in Parenterals by RP-HPLC
Abstract Views :156 |
PDF Views:0
Authors
V. Kiran Kumar
1,
N. Appala Raju
2,
Namratha Rani
2,
J. V. L. N. Seshagiri Rao
3,
T. Satyanarayana
2
Affiliations
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, AP, IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road 3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, AP, IN
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, AP, IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road 3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, AP, IN